New Centromeric Component Cenp-w Is a Rna-associated Nuclear Matrix Protein That Interacts with Nucleophosmin (b23)
نویسندگان
چکیده
NEW CENTROMERIC COMPONENT CENP-W IS A RNA-ASSOCIATED NUCLEAR MATRIX PROTEIN THAT INTERACTS WITH NUCLEOPHOSMIN (B23) Younghwa Chun, Byoungwoo Park, Wansoo Koh, Sunhee Lee, Yeongmi Cheon, Raehyung Kim, Lihua Che, and Soojin Lee Department of Microbiology and Molecular Biology, Chungnam National University, 305-764, Daejeon, Republic of Korea Running head: CENP-W interacts with B23 These authors contributed equally to this work. Address correspondence to: Soojin Lee, Ph.D. Department of Microbiology and Molecular Biology, Chungnam National University, 305-764, Daejeon, South Korea. Phone: 82-42-821-6414; Fax: 8242-822-7367; E-mail: [email protected]
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BACKGROUND Recent studies have shown that heterogeneous nuclear ribonucleoprotein U (hnRNP U), a component of the hnRNP complex, contributes to stabilize the kinetochore-microtubule interaction during mitosis. CENP-W was identified as an inner centromere component that plays crucial roles in the formation of a functional kinetochore complex. RESULTS We report that hnRNP U interacts with CENP-...
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